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Saturday, February 19, 2011

Causes of Malabsorption Syndromes

Malabsorption Syndromes

Your small intestine does most of the digesting of the foods you eat. If you have a malabsorption syndrome, your small intestine cannot absorb nutrients from foods.
Causes of malabsorption syndromes include
  • Celiac disease
  • Lactose intolerance
  • Short bowel syndrome, which happens after surgery to remove a large portion of the small intestine
  • Whipple disease, a rare bacterial infection
  • Genetic diseases
  • Certain medicines
Treatment of malabsorption syndromes depends on the cause.

Colitis, Distal colitis, Pancolitis, Ulcerative proctitis

Ulcerative Colitis


Also called: Colitis, Distal colitis, Pancolitis, Ulcerative proctitis 
 
 
Ulcerative colitis is a disease that causes ulcers in the lining of the rectum and colon. It is one of a group of diseases called inflammatory bowel disease. Ulcers form where inflammation has killed the cells that usually line the colon.
Ulcerative colitis can happen at any age, but it usually starts between the ages of 15 and 30. It tends to run in families. The most common symptoms are pain in the abdomen and bloody diarrhea. Other symptoms may include anemia, severe tiredness, weight loss, loss of appetite, bleeding from the rectum, sores on the skin and joint pain. Children with the disease may have growth problems.
About half of people with ulcerative colitis have mild symptoms. Several types of drugs can help control ulcerative colitis. Some people have long periods of remission, when they are free of symptoms. In severe cases, doctors must remove the colon.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
 

                                         Illustration of the large intestine


Adrenocortical carcinoma; Neuroblastoma; Pheochromocytoma

Adrenal Gland Cancer

A number of disorders can affect the adrenal glands, including several types of cancer. Adrenal gland cancers are uncommon. They include

  • Adrenocortical carcinoma – cancer in the outer part of the gland
  • Neuroblastoma, a type of childhood cancer
  • Pheochromocytoma
Most adrenal gland tumors are non-cancerous adenomas that usually do not cause symptoms and may not require treatment.
Symptoms of adrenal gland cancer depend on the type of cancer you have. Treatments may include surgery, chemotherapy, or radiation therapy.

Esophagectomy - diet; Post-esophagectomy diet

Diet and eating after esophagectomy


Your esophagus is a tube that moves food from your throat to your stomach. You had surgery to remove part, or all, of your esophagus. The remaining part of your esophagus was reconnected to your stomach.
You will probably have a feeding tube for 1 to 2 months after surgery. This will help you get enough calories to help you gain weight. You will also be on a special diet when you first get home.

Self-care

You may be using a feeding tube when you go home. You will probably use it only at nighttime. The feeding tube will not interfere with your normal daytime activities.
  • Your doctor or dietitian will teach you how to prepare the liquid for the feeding tube and how much to use.
  • Flush the tube with water before and after feedings. You can use seltzer to clean out any dried material that is stuck to the tube.
  • Clean all of the equipment with warm soapy water after a feeding.
You may have diarrhea when you are using a feeding tube, or even when you start eating regular foods again.
  • Notice if any specific foods are causing your diarrhea. Try to avoid these foods.
  • Try psyllium powder (Metamucil) mixed with water or orange juice. You can either drink it or put it through your feeding tube. It will add bulk to your stool and make it more solid.
  • Ask your doctor about medicines that may help with diarrhea, such as loperamide (Imodium).
What you should be eating:
  • You will be drinking liquids at first. Then you will eat soft foods for the first 4 to 8 weeks after surgery. A soft diet contains only foods that are mushy and don’t need much chewing.
  • When you are back to a normal diet, avoid steak and other dense meats because they may be hard to swallow.
Drink fluids 30 minutes after you eat solid food, and take 30 to 60 minutes to finish a drink.
Sit in a chair when you eat or drink. Do not eat or drink when you are lying down. Stand or sit for 1 hour after eating or drinking anything because gravity helps your food move downward.
Eat small meals.
  • In the first 2 weeks, eat or drink only small amounts -- no more than 1 cup at a time. It is okay to eat more than 3 times a day.
  • Your stomach will stay smaller than it was before surgery. Eating smaller meals throughout the day instead of 3 larger meals will be easier.

Alternate Names

Esophagectomy - diet; Post-esophagectomy diet

People with diabetes can have nerve problems: diabetic neuropathy.

Nerve damage from diabetes


People with diabetes can have nerve problems. This is called diabetic neuropathy.
Diabetic neuropathy happens when you have high blood sugar levels over a long time. This causes damage to the nerves that go to your legs, arms, digestive tract, heart, and bladder.
The nerve damage can cause many different problems in your body.

Symptoms

Tingling or burning in the arms and legs may be an early sign of nerve damage. These feelings often start in your toes and feet. You may have deep pain. This often happens in the feet and legs.
Nerve damage may cause you to lose feeling in your legs and arms. Because of this, you may:
  • Not notice when you step on something sharp
  • Not know you have a blister or small wound
  • Not notice when you touch something too hot or too cold
People with diabetes may have problems digesting food. These problems can make your diabetes harder to control. Symptoms of this problem are:
  • Feeling full after eating only a small amount of food
  • Heartburn and bloating
  • Nausea, constipation, or diarrhea
  • Swallowing problems
  • Throwing up undigested food several hours after a meal
Heart-related problems may include:
  • Light-headedness, or even fainting, when sitting or standing up
  • Rapid heart rate
Neuropathy may "hide" angina. This is the warning chest pain for heart disease and heart attack. People with diabetes should learn other warning signs of a heart attack. They are sudden fatigue, sweating, shortness of breath, nausea, and vomiting.
Other symptoms of nerve damage are:
  • Sexual problems. Men may have problems with erections. Women may have trouble with vaginal dryness or orgasm.
  • Not being able to tell when your blood sugar gets too low
  • Bladder problems. You may leak urine. You may not be able to tell when your bladder is full. Some people are not able to empty their bladder.
  • Sweating too much -- when the temperature is cool, when you are at rest, or at other unusual times

Treating and preventing nerve damage from diabetes

Treating diabetic neuropathy can make some symptoms of nerve problems better. The best way to keep the problem from getting worse is to have tight control of your blood sugar.
Your doctor can give you medicines to help with some of these symptoms.
  • Medicines may help reduce painful symptoms in the feet, legs, and arms. They usually do not bring back loss of feeling.
  • Your health care provider may give you medicines to help with problems going to the bathroom.
  • Other medicines can help with erection problems.
You should also:
  • Take care of your feet
  • Have a careful foot examination when you see your health care provider. These exams can find small infections. They can also keep foot injuries from getting worse.

Fracture Risk in Diabetes

Advanced Imaging Reveals Secrets of Increased Fracture Risk in Diabetes
Dateline: San Francisco, Calif.



Thomas Link, M.D., needn’t have worried that he might have to close down an imaging system critical to his work on fragility fractures in people with type 2 diabetes mellitus (T2DM). A grant from the American Recovery and Reinvestment Act (ARRA), has "reinvigorated" his osteoporosis imaging program, allowing him and his team of researchers at the University of California, San Francisco, to better understand why individuals with the T2DM have these fractures, despite the absence of low bone mineral density (BMD). The answer, he says, may be found in bone structure and composition features that his imaging facility identified.
Normal BMD, as measured by a standard imaging procedure called dual x-ray absorptiometry (DXA), does not usually indicate a higher risk for fractures. But when studies showed that women with T2DM had both normal or higher BMD and fractures, Dr. Link decided to investigate further. Using a different imaging modality called high-resolution peripheral quantitative computed tomography (hr-pQCT), he looked at bone structure in a group of elderly women with type 2 diabetes mellitus. This type of imaging system was able to reveal increases in the porosity of cortical bone (an indicator of impaired bone strength) among the T2DM women, as compared with women without the disease. Furthermore, they found a trend toward higher bone marrow fat in the women with diabetes, in particular, in those whose diabetes was not well controlled. Dr. Link now plans to expand his studies and further explore these findings.
Given the project’s success, the scientist is excited about the potential of hr-pQCT to join BMD as a possible bone biomarker for fracture risk. "Finding a strong, noninvasive bone-quality biomarker for fragility fractures in people with diabetes is clearly a major challenge area," says Dr. Link. "Based on our preliminary data, we believe that our novel biomarker may be able to better characterize fracture risk in these patients."

Cancer of the gallbladder

Gallbladder Cancer

Your gallbladder is a pear-shaped organ under your liver. It stores bile, a fluid made by your liver to digest fat. As your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. The duct connects your gallbladder and liver to your small intestine.
Cancer of the gallbladder is rare. It is more common in women and Native Americans. Symptoms include
  • Jaundice (yellowing of the skin and whites of the eyes)
  • Pain above the stomach
  • Fever
  • Nausea and vomiting
  • Bloating
  • Lumps in the abdomen
It is hard to diagnose gallbladder cancer in its early stages. Sometimes doctors find it when they remove the gallbladder for another reason. But people with gallstones rarely have gallbladder cancer. Because it is often found late, it can be hard to treat gallbladder cancer. Treatment options include surgery, chemotherapy, radiation or a combination.

GENERAL WINTER SAFETY TIPS:

All Work and Snow Play: How to Stay Safe on Your Snow Day
Orthopaedic surgeons offer commentary to help avoid injuries from the storm of the year
Rosemont, IL
With a highly anticipated blizzard making its way across the Midwest and traveling on to the East Coast, much of the country is preparing for a good old fashioned snow day. Two feet of snow expected in some areas, so many people may end up playing and sledding in the snow, while others focus on the vigorous task of snow removal. The American Academy of Orthopaedic Surgeons (AAOS) has experts available for interview, and offers advice to keep you and your children injury-free.
SNOW SHOVELING & SNOWBLOWING
AAOS EXPERT ADVICE: “Shoveling snow involves a lot of bending and heavy lifting, particularly in wet, heavy snow,” said Michael F. Schafer, MD, orthopaedic surgeon at Northwestern Memorial Hospital in Chicago and spokesperson for the AAOS. “It may be especially vigorous for people who do not regularly exercise, as their backs, shoulder and arm muscles may not be prepared for that level of activity.”
SHOVELING/SNOWBLOWING SAFETY TIPS:
  • Clear snow early and often. Begin when a light covering of snow is on the ground to avoid trying to clear packed, heavy snow.
  • Use a shovel that is comfortable for your height and strength. Do not use a shovel that is too heavy or too long for you. Consider buying a shovel that is specially designed to prevent too much stooping. Space your hands on the tool grip to increase your leverage.
  • Push the snow instead of lifting it, as much as you can. If you must lift, take small amounts of snow, and lift it with your legs: Squat with your legs apart, knees bent and back straight. Lift by straightening your legs, without bending at the waist. Then walk to where you want to dump the snow; holding a shovelful of snow with your arms outstretched puts too much weight on your spine.
  • Do not throw the snow over your shoulder or to the side. This requires a twisting motion that stresses your back.
  • Never stick your hands or feet in the snow blower! If snow becomes impacted, stop the engine and wait at least five seconds. Use a solid object to clear wet snow or debris from the chute. Beware of the recoil of the motor and blades after the machine has been turned off.
SLEDDING
AAOS EXPERT ADVICE: “It’s so important for participants to stay alert and to take breaks when they are feeling overly tired from sports like skiing, sledding or snowboarding,” said Thomas J. Nordstrom, MD, orthopaedic surgeon at the Center for Orthopaedic Care in New Jersey and AAOS spokesperson. “To avoid winter sports injury, people should keep their body as warm as possible, be in good shape, and follow the rules of the sport.”
SLEDDING SAFETY TIPS:
  • Avoid sledding near or on public streets. Sledding should be done only in designated and approved areas where there are no obstacles in the sledding path. Speeding down hills in parks that are not designed for sledding puts you at risk to be hit by cars and trucks or slam into parked vehicles, curbs, and fences.
  • Sit in a forward-facing position when sledding and steer using your feet or the rope steering handles for better control of the sled. Urge children to wear a helmet while sledding.
  • Parents or adults must supervise children in sledding areas to make sure the sledding path is safe and there are not too many sledders on the hill at the same time (or at the end of the run) to avoid collisions.
  • Be sure to carry a cell phone in case an emergency arises, and call for help if needed.
GENERAL WINTER SAFETY TIPS:
AAOS EXPERT ADVICE: “It takes only minutes for exposed skin to become frostbitten if the temperature falls below 20 degrees Fahrenheit and the wind is blowing at 20 miles per hour or more,” said Rachel Rohde, MD , orthopaedic surgeon at the William Beaumont Hospital in Michigan and spokesperson for the AAOS. “Your hands, fingers, feet, toes, and ears are especially susceptible, so you need to take special care protecting them.”
Dress appropriately. Light, layered, water-repellent clothing provides both ventilation and insulation. It also is important to wear the appropriate head coverings, as well as mittens or gloves and thick, warm socks. Take a break if you feel yourself getting too hot or too cold.
  • Check the weather for snow and ice conditions prior to participating. Pay attention to warnings about upcoming storms and severe drops in temperature to ensure safety while outdoors. Skiers, sledders and snowboarders should make adjustments for icy conditions, deep snow powder, wet snow, and adverse weather conditions.
  • Avoid frostbite:
  • Protect your head, hands and feet. Substantial heat loss occurs through the scalp, so head coverings are vital. Mittens are warmer than gloves, and two pair of socks (wool over lightweight cotton) will help keep your feet warm.
  • Don't drink or smoke before going out into the cold. If you plan on being out in the cold for a prolonged period, don't drink or smoke. Alcohol, caffeine and nicotine leave the skin more prone to thermal injury.
  • If you get wet, get inside! Remove wet clothing as quickly as possible.
  • Check yourself every half-hour or so for signs of frostbite. If your toes, fingers, ears or other body parts feel numb, get inside.

Antacids help to treat heartburn (indigestion).

Taking antacids



Antacids help to treat heartburn (indigestion). They work by changing the stomach acid that causes your heartburn.
You can buy many antacids without a prescription. Liquid forms work faster, but you may like tablets because they are easy to use.
All antacids work equally as well, but they can cause different side effects. If you use antacids often and have problems with side effects, talk with your doctor.

When to Use Antacids

Antacids are a good treatment for heartburn that does not happen very often. Take antacids about 1 hour after eating or at the time heartburn usually happens after you eat. If you are taking them for symptoms at night, do NOT take them with food.
Antacids cannot treat more serious problems, such as appendicitis, a stomach ulcer, gallstones, or bowel problems. Talk to your doctor if you have:
  • Pain or symptoms that do not get better with antacids
  • Symptoms every day or at night
  • Nausea and vomiting
  • Bleeding in your bowel movements or darkened bowel movements
  • Bloating or cramping
  • Pain in your lower belly, on your side, or in your back
  • Diarrhea that is severe or does not go away
  • Fever with your belly pain
  • Chest pain or shortness of breath
Call your doctor if you need to use antacids on most days.

Side Effects of Antacids

You may have side effects from taking these medicines. Antacids are made with three basic ingredients. If you have problems, try another brand.
  • Brands with magnesium may cause diarrhea.
  • Brands with calcium or aluminum may cause constipation.
  • Rarely, brands with calcium may cause kidney stones or other problems.
  • If you take large amounts of antacids that contain aluminum, you may be at risk for calcium loss, which can lead to weak bones (osteoporosis).
Antacids can change the way your body absorbs the other medicines you are taking. It is best to take any other medicine either 1 hour before or 4 hours after you take antacids.
Talk to your doctor or pharmacist before taking antacids on a regular basis if:
  • You have kidney disease, high blood pressure, or heart disease.
  • You are on a low-sodium diet.
  • You are already taking calcium.
  • You are taking other medicines every day.
  • You have had kidney stones.

Alternate Names

Heartburn - self-care

You had chemotherapy treatment for your cancer.

After chemotherapy - discharge



You had chemotherapy treatment for your cancer. Your risk for infections, bleeding, and skin problems may be high. You may still have mouth sores, upset stomach, and diarrhea.
You will probably get tired easily, and your appetite will be poor. You should be able to drink and eat food.

Oral Care

Brush your teeth and gums 2 to 3 times a day for 2 to 3 minutes each time. Use a toothbrush with soft bristles.
  • Let your toothbrush air dry between brushings.
  • Use a toothpaste with fluoride.
Floss gently one time a day.
Rinse your mouth 6 times a day with salt and baking soda solution (mix one half teaspoon of salt and one half teaspoon of baking soda in 8 ounces or 1 cup of water).
Do not use mouth rinses with alcohol in them. Use your regular lip care products to keep your lips from drying and cracking. Tell your doctor if you develop new mouth sores or mouth pain.
Chew sugarless gum or suck on sugar-free popsicles or hard candies. Do not eat foods and drinks with a lot of sugar.
Take care of your dentures, braces, or other dental products.
If you wear dentures, put them in only when you eat. Do this for the first 3 to 4 weeks after your transplant.

Preventing Infections

You need to be careful not to get infections.
Practice safe eating and drinking.
  • Be careful what you eat. Do not eat or drink anything that may be undercooked or spoiled.
  • Make sure your water is safe.
  • Know how to cook and store foods safely.
  • Be careful when you eat out. Do not eat raw vegetables, meat, or fish, or anything else you are not sure is safe.
See also:
  • Safe eating during cancer treatment
  • Safe drinking during cancer treatment
Wash your hands with soap and water often:
  • After being outdoors
  • After touching body fluids, such as mucus or blood
  • After changing a diaper
  • Before handling food
  • After using the telephone
  • After doing housework
  • After going to the bathroom
Keep your house clean. Stay away from crowds. Ask visitors who have a cold to wear a mask or not to visit. Do not do yard work or handle flowers and plants.
Be careful with pets and animals:
  • If you have a cat, keep it inside.
  • Have someone else change the litter box every day.
  • Do not play rough with cats. Scratches and bites can get infected.
  • Stay away from puppies, kittens and other very young animals.
Ask your doctor what vaccines you may need and when to get them.

Self-care

Know how to care for your central venous line or PICC line.
If your doctor or nurse tells you your platelet count is still low, learn how to prevent bleeding. See also: Bleeding during cancer treatment
Start to walk. Slowly increase how far you go based on how much energy you have.
You need to eat enough protein and calories to keep your weight up. See also: Eating extra calories when you are sick - adults
Ask your doctor about liquid food supplements. These can help you get enough calories and nutrition.
Be careful about being in the sun. Wear a hat with a wide brim. Use sunscreen with SPF 30 or higher on any areas of exposed skin. Do not smoke.

Follow-up

You will need close follow-up care with your cancer doctor and nurse.

When to Call the Doctor

If you have any of these symptoms, call your doctor:
  • Fevers, chills, or sweats. These may be signs of infection.
  • Diarrhea that does not go away or is bloody
  • Severe nausea and vomiting
  • Being unable to eat or drink
  • Extreme weakness
  • Redness, swelling, or drainage from any place where you have an IV line inserted into your body
  • A new skin rash or blisters
  • Jaundice (the white part of your eyes or skin looks yellow)
  • Pain in your stomach area
  • A very bad headache or one that does not go away
  • A cough that is getting worse
  • Trouble breathing when you are at rest or when you are doing simple tasks
  • Burning when you urinate

Bilirubin may have a protective effect, researchers say

Higher Levels of Blood Protein Linked to Lower Respiratory Risks

Bilirubin may have a protective effect, researchers say

HealthDay news image(Healthline News) -- People whose blood levels of bilirubin are on the high side may have a lowered risk for lung cancer, chronic obstructive pulmonary disease (COPD) and death from any cause, British researchers report. Bilirubin is a protein made as the hemoglobin in red blood cells breaks down. It is in excreted urine, and high levels may indicate certain diseases. It is responsible for the yellow color of bruises and the yellow discoloration in jaundice. Bilirubin may also have antioxidant and anti-inflammatory effects, which help protect cells, the researchers said.
"Bilirubin levels, which are routinely tested in patients mainly to assess liver function, may also be useful for assessing the risk of respiratory disease and death," said lead researcher Laura J. Horsfall, from the Division of Biosciences at University College London.
Animal studies have shown that raised bilirubin levels in the blood appears to protect the lungs against environmental damage, which may be due to the potent antioxidant and anti-inflammatory properties of bilirubin, she added.
"There are already a number of studies showing that moderately higher bilirubin levels in people without evidence of liver disease are associated with lower rates of heart disease," Horsfall said.
"We have now shown similar associations for COPD, another important cause of global morbidity and mortality. Thus, within the range typically considered normal, bilirubin may be useful for objectively quantifying a patient's risk of a range of common diseases," she said.
More work is needed to see if higher blood bilirubin levels reduce the risk of lung disease and death itself, or if they're a marker for lower exposure to other factors, such as air pollution and passive smoking, Horsfall noted.
For the study, which is published in the Feb. 16 issue of the Journal of the American Medical Association, Horsfall's team collected data on the bilirubin levels of 504,206 people who were part of the United Kingdom's Health Improvement Network.
The researchers found that high normal levels of bilirubin were linked with a reduced risk of respiratory diseases and death from any cause.
In fact, among men, every 0.1 milligram per deciliter (mg/dL) increase in bilirubin was associated with an 8 percent decrease in lung cancer risk. Among women, the same increase in bilirubin was associated with an 11 percent decreased risk, Horsfall's group found.
In addition, for men, each 0.1-mg/dL increase in bilirubin was associated with a 6 percent lower risk for COPD and a 3 percent decreased risk of death. The findings were similar for women, the researchers noted.
Commenting on the study, Dr. Eugene R. Schiff, director of the Center for Liver Diseases at the University of Miami School of Medicine, said that "this is something that really surprised me."
"What they don't know is, if this correlation is real, why is it," he said. "This whole thing could turn out not to be real."
However, Schiff thinks that if the effect is real, it is not due to bilirubin itself. "If there is an association, the bilirubin itself is not doing it. It's not the bilirubin; it's what is responsible for a relatively high bilirubin," he said.
Schiff speculated that genetics might be at work.

Prednisone is a corticosteroid

Prednisone

Description

Prednisone is a corticosteroid. In contrast to anabolic steroids (used by “bodybuilders”), corticosteroids are used in inflammatory conditions for their anti–inflammatory effects. They have a rapid onset of action, and profoundly affect many parts of the immune system as well as most other body systems. Corticosteroids are a cornerstone of treating most types of vasculitis, and are often used in combination with other immunosuppressive medications.

Side Effects

Many of the side–effects of steroids are predictable. All are related to: 1) the amount of steroid a patient takes in his/her daily dose, and 2) the length of time the patient remains on the medication. We emphasize that not all side–effects occur in all patients.
Despite the numerous potential side–effects of corticosteroids listed below, their introduction into patient care 50 years ago revolutionized the treatment of many diseases, including vasculitis. When used properly, these drugs save lives and avert threats to the function of important organs.
One of the numerous potential side–effects of prednisone and other forms of corticosteroid treatment is hirsutism — excessive growth of body hair. Patients vary in the degree to which this side–effect of steroids occurs. Although some experience minimal hirsutism, the patient depicted here developed this side effect after taking 10 milligrams of prednisone for a few months.
Facial Hair
  • Weight Gain
  • Glucose Intolerance
  • Hypertension
  • Increased Susceptibility to Infections
  • Bone Thinning
  • Easy Bruising
  • Mood Swings/Insomnia
  • Avascular Necrosis of bone
  • Abdominal Striae
  • Cataracts
  • Acne

Weight Gain

Weight gain is usually the most dreaded side–effects of steroid use, incurred to some degree by nearly all patients who take them. The amount of weight gain varies from individual to individual. In addition to causing weight gain, prednisone leads to a redistribution of body fat to places that are undesirable, particularly the face, back of the neck, and abdomen. Pictured below is a example of redistribution of body fat to the back of the neck. Accumulation of fat in this area is sometimes referred to as a “buffalo hump”.
Hump
Another example of this “redistribution” is pictured below. Supraclavical “fat pads” are collections of fat at the base of the neck, just above the collarbones, which are common in patients on steroids. They sometimes cause concern among patients if mistaken for lymph nodes or other causes for worry, but will gradually subside as the prednisone dose is tapered to below 10 milligrams/day.
Neck

Glucose Intolerance

High blood sugar, or steroid–induced diabetes. This usually resolves when the steroids are decreased or discontinued.

Hypertension

High blood pressure. This usually improves as the corticosteroid dose is reduced.

Increased Susceptibility to Infections

Patients are at increased risk for many types of infections, from minor fungal infections in the mouth (“thrush”, caused by Candida) to life–threatening infections such as Pneumocystis carinii pneumonia. The higher the steroid dose and the longer the duration of therapy, the greater the risk of infection. The risk is also increased when patients receive combinations of immunosuppressive medications, such as cyclophosphamide (cytoxan) and prednisone. The risk of some infections can be greatly reduced by taking specific types of antibiotics prophylactically.
Pictured below is woman under treatment with prednisone and methotrexate for vasculitis and a concurrent neurologic condition (myasthenia gravis) developed painful vesicles in her mouth. The vesicles were confirmed by culture to be caused by re–activation of a Herpes simplex infection, and responded to treatment with acyclovir.
Herpes

Bone Thinning (Osteoporosis)

Prednisone may cause thinning of the bones even in people who are not usually at high risk for osteoporosis (for example: males, young people). In people susceptible to osteoporosis, prednisone may accelerate the process of bone loss. Fortunately, in the past few years, excellent treatments and preventive measures have become available for osteoporosis. All patients on prednisone for prolonged periods are candidates for these medicines.

Easy Bruising

Prednisone also causes “thin skin”. Patients on moderate to high doses of prednisone often notice that they bruise easily, even with only slight trauma. Pictured below is a patient with giant cell arteritis who suffered a skin laceration after she struck her leg against a chair.
Skin

Mood Swings/Insomnia

Many patients find it difficult to sleep when taking high doses of steroids. Many also find that they are more irritable than usual. Steroids sometimes even induce depression, which improves when the drug is decreased or discontinued.

Avascular Necrosis of Bone

For reasons that are not known, high dose prednisone (for example, greater than 20 milligrams a day) predisposes some patients to joint damage, most often of the hips. In avascular necrosis (or osteonecrosis, meaning “bone death”) of the hip, the part of the leg bone that inserts into the pelvis dies, resulting in pain with weight–bearing and some loss of joint function. Many patients with avascular necrosis require joint replacements.

Abdominal Striae

Abdominal striae (“stripes”), as pictured below, frequently occur in patients who take high doses of steroids for long periods of time.
Abdominal Striae

Cataracts

Long–term steroid use may lead to cataract development in the eyes, which frequently require surgical removal.

Acne

High dose prednisone predisposes some patients to acne, especially facial acne, as pictured below. The facial acne developed after several weeks of high steroid doses.
Acne

Years ago, tall girls often received hormones to stunt their growth

Stunting tall girls' growth may impact fertility


By Genevra Pittman
NEW YORK (Reuters Health) - Years ago, tall girls often received hormones to stunt their growth -- and now as adults they seem to have more difficulty becoming pregnant than women who weren't treated, a new Dutch study reveals.
The study is the second to show that stunting girls' growth, which was widely done in Europe, Australia, and the United States starting in the 1950's, may have long-term consequences on their reproductive systems.
The treatment involves high doses of the female hormone estrogen. Purposely stunting the growth of tall girls is less common today, but it's not unheard of.
The message from the findings needs to reach girls who are considering treatment, because the risk of reduced fertility may outweigh the benefit of reduced height, said Dr. Emile Hendriks, the lead author of the study from the Erasmus Medical Center in Rotterdam, The Netherlands in email to Reuters Health. "It also needs to reach treated women who need to be well informed when they consider their family planning."
This use for estrogen gained popularity about 50 years ago after researchers found it might limit the growth of girls who were much taller than their peers in adolescence. According to one estimate, up to 5,000 girls in the U.S. were treated with estrogen, and many more in Europe.
At that time, "women were basically supposed to get married and have children, and that would be harder if you were a very tall woman, everybody believed," Christine Cosgrove, co-author of Normal at Any Cost: Tall Girls, Short Boys, and the Medical Industry's Quest to Manipulate Height, told Reuters Health.
"There were so many parents, mostly mothers probably, who just feared that their daughters' lives would be ruined if they ended up being six feet tall, because they'd never have a husband and a family," she said.
Some tall girls are still treated with estrogen today -- more in Europe than in the United States -- and estrogen is currently given to these girls in about the same dose that is in a birth control pill, Cosgrove said. In the past, it might have been given at 100 times that dose before doctors realized the potential dangers, she said.
For the current study, Hendriks and his colleagues recruited 239 Dutch women who had been treated as adolescents between 1968 and 1998 with high doses of estrogen to stunt their growth. They also gathered another group of tall women who had not been treated. All of the women filled out questionnaires about their attempts to conceive and any fertility treatment they had needed.
Women who had the estrogen treatment were more likely to have trouble conceiving than untreated women, according to results published in the Journal of Clinical Endocrinology & Metabolism.
Of those who had tried to get pregnant after being treated with estrogen, 82 percent successfully conceived, compared to 95 percent of untreated women who conceived.
And 71 percent of the treated women gave birth to a live baby, compared to 90 percent of the untreated group.
It also took women treated with estrogen longer to get pregnant -- 56 percent were able to conceive in less than a year of trying, whereas 79 percent of untreated women got pregnant over that same time span. In addition, estrogen-treated women were more likely to get infertility treatment or to visit a doctor for problems related to infertility.
Some of the women in each group underwent tests to determine how well their ovaries were functioning. It turned out that treated women were almost three times as likely to have ovaries that showed signs they might be about to fail, based on hormone levels. That could be one of the reasons these women had more trouble getting pregnant, according to the authors.
The study is important because it's only the second one of its kind, researchers say, although the finding that high doses of estrogen in adolescence may impact fertility later on isn't necessarily surprising.
In an interview with Reuters Health, Dr. Donna Baird, who heads the Women's Health Group at the National Institute of Environmental Health Sciences and was one of the authors of the first study to show this link, said, "The time when (the ovary) is developing in adolescence is clearly an important time. Anything that a girl is exposed to at that time may have much more effect."
Some boys have also been treated with hormones -- in their case, testosterone -- in attempts to stunt their growth. One study suggested testosterone treatment may not affect boys' fertility in the future but is linked to lower testosterone levels when they become adults (see Reuters Health story of October 27, 2010.)
In the opposite scenario, treating short kids with growth hormone during adolescence to help them grow taller has been gaining in popularity in recent years. Until recently, this treatment was only used when there was a medical reason for short stature. The treatment was only started on kids with no medical basis to their short stature within the last decade, and "we don't have the real long-term data," Dr. Joyce Lee, a pediatric endocrinologist in the University of Michigan Health System who was not involved in the current research, told Reuters Health. "We need to wait 30 years to find that answer."
In another recent study, many doctors said they would keep treating short kids with growth hormone even if they weren't responding after a year on the treatment (see Reuters Health story of August 30, 2010.)
"There's always going to be unknown consequences of any medical therapy," Lee said. "The important lesson is, (estrogen) wasn't really prescribed for life-threatening causes," just as growth hormone treatment isn't generally a life-or-death matter today.
"Being tall or being short isn't a disease in most cases," Cosgrove said. "These efforts to treat it as one I think are probably doomed to backfire, and they seem to be backfiring now."

When you are on a low residue fiber diet

Low-residue fiber diet


When you are on a low residue fiber diet, you will eat low-fiber foods that are easy for your body to digest. Eating these foods will slow down your bowel movements.
This diet includes foods you are used to eating, like cooked vegetables, fruits, white breads, and meats. It does NOT include foods that make your bowels work more, like beans and legumes, whole grains, many raw vegetables and fruits, and nuts and seeds.
Your goal is to eat less than 10 to 15 grams of fiber each day.
This diet gives you proteins, fluids, salts, and minerals you need. With the right food choices, you can get enough nutrition from this diet. You may have to take supplements, such as vitamin C, calcium, folic acid, and others if you are on this diet for a long time. Check with your doctor.

Why You Need This Diet

You may need to be on a low residue fiber diet if you have diverticulitis, Crohn’s disease, ulcerative colitis, or bowel inflammation. Sometimes people are put on this diet after certain kinds of surgery, such as an ileostomy or colostomy. You may need to follow this diet only for a short period of time or for the rest of your life. Your doctor may refer you to a dietitian for help with meal planning.

What You Can Eat and Drink

Here are some of the foods recommended for a low residue fiber diet.
Milk products:
  • You may have up to 2 cups total of smooth milk products a day. This includes yogurt, cottage cheese, milk, pudding, or creamy soup, or 1.5 ounces of hard cheese.
  • Avoid milk products with nuts, seeds, fruit, or vegetables added to them.
Breads and grains:
  • You may have refined white breads, dry cereals (Special K, puffed rice, Corn Flakes, Rice Krispies), white pasta, and crackers. Make sure these foods have less than a half (0.5) a gram of fiber per serving.
  • Do NOT eat whole-grain breads, crackers and cereals, whole-wheat pasta, and brown rice.
Vegetables: You may eat these vegetables raw:
  • Lettuce
  • Cucumbers
  • Onions
  • Zucchini
You can eat these vegetables if they are well-cooked or canned (without seeds). You can also drink juices made from them if they do not contain seeds or pulp:
  • Yellow squash (without seeds)
  • Spinach
  • Pumpkin
  • Eggplant
  • Potatoes, without skin
  • Green beans
  • Wax beans
  • Asparagus
  • Beets
  • Carrots
Do NOT eat any vegetable that is not on the list above. Do NOT eat vegetables raw that are okay to eat cooked. Avoid vegetables and sauces with seeds, such as tomato sauce. Do NOT eat popcorn.
Fruits:
  • You may have fruit juices without pulp and many canned fruits or fruit sauces, such as applesauce.
  • Raw fruits you can have are very ripe apricots, bananas and cantaloupe, honeydew melon, watermelon, nectarines, papayas, peaches, and plums. Avoid all other raw fruit.
  • Fruits to avoid are canned or raw pineapple, fresh figs, berries, all dried fruits, fruit seeds, and prunes and prune juice.
Protein:
  • You may eat cooked meat (including bacon), fish, poultry, eggs, and smooth peanut butter. Make sure your meats are tender and soft, not chewy with gristle.
  • Avoid deli meats, crunchy peanut butter, nuts, beans, tofu, and peas.
Fats, oils, and sauces:
  • You may eat butter, margarine, oils, mayonnaise, whipped cream, and smooth sauces and dressings.
  • Smooth condiments are okay.
  • Do NOT eat very spicy foods and dressings. Avoid chunky relishes and pickles.
Other foods and drinks:
  • You may eat plain cakes, cookies, pies, Jell-O, sugar, and hard candies.
  • Do not eat desserts that contain fruits that are not okay to eat, nuts, or coconut. Avoid chocolate that contains cocoa powder.
  • Avoid caffeine.
  • Ask your doctor if alcohol is okay.

Alternate Names

Fiber diet - low-residue; Low-fiber diet

General information on diabetes and prediabetes

National Diabetes Fact Sheet, 2011
      Citation
Centers for Disease Control and Prevention. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011.
CS217080A
FAST FACTS ON DIABETES
Diabetes affects 25.8 million people 8.3% of the U.S. population
Among U.S. residents aged 65 years and older, 10.9 million, or 26.9%, •     had diabetes in 2010.
About 215,000 people younger than 20 years had diabetes (type 1 or •     type 2) in the United States in 2010.
About 1.9 million people aged 20 years or older were newly •     diagnosed with diabetes in 2010 in the United States.
In 2005–2008, based on fasting glucose or hemoglobin A1c levels, •     35% of U.S. adults aged 20 years or older had prediabetes (50% of
adults aged 65 years or older).  Applying this percentage to the entire U.S. population in 2010 yields an estimated 79 million American adults aged 20 years or older with prediabetes.
Diabetes is the leading cause of kidney failure, nontraumatic lower-•     limb amputations, and new cases of blindness among adults in the
United States.
DIAGNOSED 18.8 million people
UNDIAGNOSED 7.0 million people
Diabetes is a major cause of heart disease and stroke.•  
Diabetes is the seventh leading cause of death in the United States.•  
National Center for Chronic Disease Prevention and Health Promotion Division of Diabetes Translation
All ages, 2010
 click here to download pdf

http://links.govdelivery.com/track?type=click&

In many counties in those regions, more than 29 percent of adults reported getting no physical activity or exercise other than at their regular job.

Highest Rates of Leisure-Time Physical Inactivity in Appalachia and South

CDC releases new estimates for all U.S. counties

Americans who live in parts of Appalachia and the South are the least likely to be physically active in their leisure time, according to estimates released today by the Centers for Disease Control and Prevention. In many counties in those regions, more than 29 percent of adults reported getting no physical activity or exercise other than at their regular job.
 provide county-level estimates for leisure-time physical inactivity for all U.S. counties. Areas where residents are most likely to be active in their free time are the West Coast, Colorado, Minnesota and parts of the Northeast.
States where residents are the least likely to be physically active during leisure time are Alabama, Kentucky, Louisiana, Mississippi, Oklahoma and Tennessee. In those states, physical inactivity rates are 29.2 percent or greater for more than 70 percent of the counties.
A 2008 CDC survey found that 25.4 percent of U.S. adults did not spend any of their free time being physically active, including activities such as walking for exercise, gardening, golfing or running.
CDC previously released maps with estimated levels of diabetes and obesity for all U.S. counties. Combining all three factors produces a map that shows the highest levels of diagnosed diabetes, leisure-time physical inactivity and obesity in the South and parts of Appalachia. The regions with the lowest levels of all three are the West and Northeast.
Physical activity can help control weight, reduce the risk of type 2 diabetes, heart disease and some cancers, strengthen bones and muscles, and improve mental health.
"Physical activity is crucial to managing diabetes and reducing serious complications of the disease," said Ann Albright, Ph.D., R.D., director of CDC's Division of Diabetes Translation. "Moderate intensity activities such as dancing or brisk walking, for just 150 minutes a week, can significantly improve the health of people with diabetes or at high risk for the disease."
The county level leisure-time physical inactivity estimates come from CDC's Behavioral Risk Factor Surveillance System, which uses self-reported data from state-based adult telephone surveys, and 2007 census information. Those participating in the survey were asked if they participated in any physical activities or exercise outside of their regular job.
Community organizations and policymakers can use this information to support health-promoting urban design, land use, and transportation policies in their state, community or neighborhoods. "Chronic diseases, like diabetes, are a burden on our health care system," said Janet E. Fulton, Ph.D., of CDC's Division of Nutrition, Physical Activity and Obesity. "We need changes in communities that make it safe and easy to be active. Sidewalks, street lights, and access to parks or recreation areas can encourage people to get out and move more."
CDC and its partners are working on a variety of initiatives to increase physical activity, reduce obesity and prevent type 2 diabetes. CDC funds 25 states through the state-based Nutrition, Physical Activity and Obesity program that coordinates statewide efforts with multiple partners to address obesity and other chronic conditions. Communities Putting Prevention to Work is a two-year program through which communities and states are funded to reduce the burden of chronic diseases related to obesity and tobacco use through policy, systems and environmental change.
CDC's National Diabetes Prevention Program supports establishing a network of lifestyle intervention programs for overweight or obese people at high risk of developing type 2 diabetes. These interventions emphasize dietary changes, coping skills and group support to help participants lose 5 percent to 7 percent of their body weight and get at least 150 minutes per week of moderate physical activity.

Australian researchers are challenging guidelines that urge diabetics to cut back on salt in their diet.


 cast on salt guidelines for diabetics

By Frederik Joelving

NEW YORK (Reuters Health) - Australian researchers are challenging guidelines that urge diabetics to cut back on salt in their diet.
In a study that seems to turn conventional wisdom on its head, they found patients with the highest levels of sodium in their urine had the smallest risk of dying over a 10-year period.
"Such data call into question universal recommendations that all adults should endeavor to reduce their salt intake," Dr. Elif I. Ekinci of the University of Melbourne in Victoria and colleagues write in the journal Diabetes Care.
But don't reach for the pretzels just yet.
Although it isn't the first time findings like these have surfaced, the Australian researchers, like others before them, relied on observations only and didn't actually run an experiment to test the direct impact of eating more or less salt.
Instead, they followed 638 people with longstanding type 2 diabetes, often accompanied by heart disease and high blood pressure. At the outset of the study, all the patients were in their 60s on average and nearly half of them were obese.
"These are precisely the patients in whom more aggressive lifestyle interventions are often applied," the researchers note.
All the patients were treated at a single diabetes clinic, and doctors determined the daily amount of sodium in their urine when the study began. That's the gold standard of measuring salt intake, because it doesn't rely on patients remembering or jotting down what they ate.
The average amount of sodium in their urine, 4.2 grams per day, was in line with earlier global surveys, the researchers say.
Over the decade the study spanned, 175 patients died, mostly due to heart disease.
For every extra 2.3 grams of sodium in their urine, their risk of dying during the study dropped by 28 percent -- even after accounting for kidney disease, age and other factors likely to be important.
"This is unexpected," Dr. Ekinci and Dr. George Jerums, who also worked on the study, told Reuters Health by e-mail. "It raises the possibility that in people with type 2 diabetes, low salt intake is not always beneficial."
More than 23 million Americans have type 2 diabetes. According to the 2010 Dietary Guidelines for Americans, they should eat no more than 1.5 grams of sodium -- about two-thirds of a teaspoon of salt -- per day.
Most Americans consume more than twice that amount, U.S. government researchers said last year in a study that pointed to foods like pizza, cookies and meats as the main culprits.
At this point, nobody is recommending any change to the current dietary advice, because the new study doesn't prove that extra salt helps diabetics live longer.
The main problem is that the patients who had lower sodium levels in their urine were sicker and older, said Dr. Paul Elliott, who studies the link between diet and high blood pressure at Imperial College London.
"Although the authors used statistical models to try to 'correct' for these imbalances, it remains likely that the results are still confounded by them," he said.
That reasoning seems to be bolstered by the finding that higher blood pressure was tied to longer survival in the study, "which just isn't plausible," Elliott added in an email to Reuters Health.
But another expert said the Australian researchers might be onto something.
"The reality is that reducing sodium has many effects, some good like reducing average blood pressure, and others bad," said Dr. Michael H. Alderman of the Albert Einstein College of Medicine in New York.
For instance, he said, reducing sodium increases insulin resistance, which is the main problem in diabetes. It also ups the production of certain other hormones that have been linked to heart disease.
"The impact of reducing sodium must be the sum total of all these physiological effects," Alderman told Reuters Health in an e-mail.
To get to the bottom of the issue, a clinical trial comparing people told to eat less sodium to those who maintain their usual intake is necessary.
"It is surely safer, and probably cheaper than to ask 300 million Americans to reduce their sodium intake because of the hope that it will actually extend or improve life," Alderman said.

Thursday, February 17, 2011

A bland diet can be used to treat ulcers

Bland diet


A bland diet can be used to treat ulcers, heartburn, nausea, vomiting, and gas. You may also need a bland diet after stomach or intestinal surgery.
A bland diet is made up of foods that are soft, not very spicy, and low in fiber. If you are on a bland diet, you should not eat spicy, fried, or raw foods. You should not drink alcohol or drinks with caffeine in them.
Your doctor or nurse will tell you when you can start eating other foods again. It is still important to eat healthy foods when you add foods back in. Your doctor can refer you to a dietitian or nutritionist to help you plan a healthy diet.

Foods You Can Eat

Here some foods you can eat on a bland diet:
  • Milk and other dairy products, low-fat only
  • Cooked, canned, or frozen vegetables
  • Fruit and vegetable juices
  • Cooked or canned fruit with the skin and seeds removed, such as applesauce or canned peaches
  • Breads, crackers, and pasta made with refined white flour
  • Refined hot cereals, such as oatmeal and cream of wheat
  • Lean, tender meats, such as poultry, whitefish, and shellfish that are steamed, baked, or grilled with no added fat
  • Creamy peanut butter
  • Pudding and custard
  • Eggs
  • Tofu
  • Soup, especially broth
  • Weak tea

Foods to Avoid

Here are some foods you should NOT eat when you are on a bland diet:
  • Fatty dairy foods, such as whipped cream or high-fat ice cream
  • Strong cheeses, such as bleu or Roquefort
  • Raw vegetables
  • Vegetables that make you gassy, such as broccoli, cabbage, cauliflower, cucumber, green peppers, and corn
  • Fresh berries and other fresh fruit
  • Dried fruit
  • Whole-grain or bran cereals
  • Whole-grain breads, crackers, or pasta
  • Pickles, sauerkraut, and similar foods
  • Spices, such as hot pepper and garlic
  • Foods with a lot of sugar or honey in them
  • Seeds and nuts
  • Highly seasoned cured or smoked meats and fish
  • Fried foods
You should also avoid medicine that contains aspirin or ibuprofen (Advil, Motrin)

Other Diet Tips

Here are some tips for when you are on a bland diet:
  • Eat small meals, and eat more often during the day.
  • Chew your food slowly, and chew it well.
  • Stop cigarette smoking, if you smoke.
  • Do not eat within 2 hours of when you go to bed.
  • Stop eating foods that are NOT on the "do not" list if you don’t feel well after eating them.
  • Drink fluids slowly.

Antibiotics are strong medicines that can kill bacteria.

Antibiotics: When Do They Help

Select New Symptom

Definition

Antibiotics are strong medicines that can kill bacteria. Antibiotics have saved many lives and prevented bacterial complications. However, antibiotics do not kill viruses. One of the decisions healthcare providers make every day is whether a child's infection is viral or bacterial. Consider their perspective.

Bacterial Infections: Antibiotics can help and will be prescribed

Bacterial infections are much less common than viral infections. Bacteria cause:
  • Most ear infections (but they only happen to 5% of children with a cold)
  • Most sinus infections (but they only happen to 5% of children with a cold)
  • 20% of sore throats (Strep throat infections)
  • 10% of pneumonia (bacterial lung infection)

Viral Infections: Antibiotics do NOT help

Viruses cause most infections in children including:
  • Colds present for less than 2 weeks, unless they turn into an ear or sinus infection
  • Coughs present for less than 3 weeks, unless they develop a bacterial pneumonia
  • 95% of fevers
  • 80% of sore throats
  • 90% of pneumonia (most pneumonia in children is viral)
  • 99% of diarrhea and vomiting

Cold Symptoms that are Confusing but Normal

These symptoms are sometimes mistaken as signs of bacterial infections and a reason for starting antibiotics:
  • Green or yellow nasal discharge. Green or yellow discharge is usually a normal part of recovery from a cold, rather than a clue to a sinus infection.
  • Green or yellow phlegm (sputum). This is a normal part of viral bronchitis, not a sign of pneumonia.
  • High fevers. A high fever (over 104 F or 40 C) can be caused by a virus or a bacteria.

Side Effects of Antibiotics

All antibiotics have side effects. Unless your child really needs an antibiotic, there is no reason to risk the side effects of the medicine. Some children taking antibiotics develop diarrhea, nausea, vomiting, or a rash. The diarrhea usually occurs because the antibiotic has killed off the healthy intestinal bacteria. And if your child gets a rash, your doctor must decide if the rash is an allergic reaction to the drug or not. The biggest side effect of overuse is increasing resistance to the antibiotics.

Giving Antibiotics for Viral Infections: What Happens?

If your child has a viral illness, an antibiotic will not shorten the course of the fever or help the other symptoms. Antibiotics will not get your child back to school or you back to work sooner. If your child develops side effects from the antibiotic, he will feel worse instead of better.

What You Can Do

  • Save antibiotics for diagnosed bacterial infections when your child really needs them
  • Don’t pressure your child’s doctor for a prescription for an antibiotic
  • Treat your child’s cold and cough symptoms with home remedies that work
  • Remember that fever is fighting the infection and producing antibodies to prevent future viral infections.

Another reason second-hand smoke is bad: there's a chance it can damage the tissues in a woman's cervix

Second-hand smoke ups risk of abnormal Pap test


By Amy Norton
NEW YORK (Reuters Health) - Another reason second-hand smoke is bad: there's a chance it can damage the tissues in a woman's cervix, putting her at higher risk for cervical cancer, a new study suggests.
Women smokers have a higher-than-average risk of cervical cancer. The new research did not show that women who inhale other people's smoke are also more likely to end up with that cancer -- but it did show they have a higher risk of having damaged cells in their cervix.
This kind of damage is what doctors look for with Pap tests when they're screening for cervical cancer.
The findings do not prove that second-hand smoke itself is responsible for the cervical abnormalities.
But the results, which came from a study of 4,400 women undergoing Pap tests, do show that "women who report exposure to second-hand smoke are more likely to have an abnormal Pap test than women who do not report exposure to second-hand smoke," said lead researcher Dr. Kristy K. Ward, of the University of California San Diego.
An abnormal Pap test doesn't mean a woman has cervical cancer. In fact, most women with abnormal Pap results do not go on to develop the cancer. But they do need further testing, and sometimes surgery.
The main cause of cervical cancer is persistent infection with certain strains of the human papillomavirus (HPV), which causes genital warts.
It's possible that second-hand smoke makes a woman more vulnerable to developing abnormalities in cervical tissue, according to Ward.
Active smoking has already been linked to an increased risk of cervical cancer, and studies have shown that toxins from both first-hand and second-hand cigarette smoke can be found in cervical tissue.
"In general," Ward told Reuters Health in an email, carcinogens -- the cancer-causing material in tobacco smoke -- "cause the genetic material in the cell to change, so it doesn't function normally. This can lead to abnormalities in the cell that show up on a Pap test and have the potential for progressing to cancer."
Past studies have found a link between second-hand smoke and abnormal Pap results -- but other studies have failed to confirm the connection. This latest study is different in that most of the women involved were Hispanic American.
Hispanic women in the U.S. develop cervical cancer at a rate of 11.5 per 100,000 women -- versus 8 per 100,000 among U.S. women in general.
Of the 4,400 women in this study, about one in every 14 had an abnormal Pap test result.
Overall, the researchers found, women who said they were exposed to "some" second-hand smoke were 70 percent more likely to have an abnormal Pap result than women with no such exposure -- even after other factors, like a woman's own smoking and sexual history, were taken into account.
The results do not specify what the risk of an abnormal Pap smear would be with and without exposure to second-hand smoke. But Ward said any actual increase in risk would be small.
Still, the findings offer yet another potential reason to steer clear of second-hand smoke -- which is already linked to increased risks of asthma and respiratory infections in children, and heart disease and lung cancer in adults.
"Our study once again shows that second-hand smoke exposure is dangerous to a person's health," Ward said.
She also noted that even though most cervical abnormalities on Pap tests will not lead to cancer, at a minimum they lead to extra stress and expenses.
"Personally," Ward said, "a woman with an abnormal Pap test experiences anxiety about the potential of a pre-cancerous or cancerous disease, and it requires extra time, effort and money to continue to return to the health care provider's office for follow-up and treatment."

Atrial fibrillation patients not suited for warfarin

New Guidelines OK Pradaxa Blood Thinner as Option for Irregular Heartbeat

Updated recommendation is for atrial fibrillation patients not suited for warfarin


HealthDay news image(Healthline News) -- For patients with the heart rhythm disorder atrial fibrillation, a new anti-clotting drug called Pradaxa (dabigatran) can be used as an alternative to warfarin, according to updated guidelines released Monday. About 2 million Americans have atrial fibrillation, in which the heart's two upper chambers beat erratically, causing uneven and inefficient pumping of blood. As a result, blood can pool and clot in the chambers, raising the risk of stroke or heart attack. Since the 1950s, such patients have been prescribed warfarin, but the drug requires regular testing and dosage adjustments.
The updated guidelines, issued by the American College of Cardiology, American Heart Association and the Heart Rhythm Society, say that Pradaxa can be used to prevent blood clots and stroke in patients with either recurrent episodes of atrial fibrillation that stop after seven days (called "paroxysmal") or ongoing ("permanent") atrial fibrillation, and with risk factors for blood clotting and stroke, provided that they don't have a prosthetic heart valve, significant heart valve disease, severe kidney failure or advanced liver disease.
The updated guidelines are published in the journals Circulation, HeartRhythm and the Journal of the American College of Cardiology.
Last December, the groups released an updated guideline that said a combination of aspirin and the drug Plavix (clopidogrel) could be used to prevent blood clots and stroke in atrial fibrillation patients who are poor candidates for warfarin.

neuroscientists have significantly advanced brain-computer interface (BCI) technology

Brain-Controlled Prosthetics
 
Motorlab, University of Pittsburgh School of Medicine.
A rhesus monkey with its arms gently restrained (and thus immobilized) feeds itself by operating a prosthetic arm with its mind. This research was supported by the National Institutes of Health, and shows how knowledge generated by neuroscience research on animals has led to important advances in understanding and treating physical disabilities. 
PDF icon

your   health is in your  own hands so
take care of yourself..........                                                         

Mind over matter is no longer the stuff of science fiction alone. After years of basic research, neuroscientists have significantly advanced brain-computer interface (BCI) technology to the point where severely physically disabled people who cannot contract even one leg or arm muscle have independently composed and sent e-mails and operated a TV in their homes. They used only their thoughts to execute these actions.
Thoughts can operate machines. With the aid of a tiny brain implant known as a brain-computer interface (BCI), scientists have developed technology that enables communication between brain activity and an external device. People almost completely paralyzed by an earlier spinal cord injury have been able to turn on a television, access e-mail on a computer, play simple video games, and even grasp a piece of candy and hand it to someone using a robotic hand—all by thinking about such movements and then having a computer translate those thoughts into action.
Recent studies involving monkeys have shown that the brain can even accept a mechanical arm as its own, manipulating it like a normal limb to perform a complex motor task, such as grabbing and eating food.
These and other remarkable advances in neural (brain-controlled) prosthetics are the result of decades of basic research into how the brain turns thought into physical action. Such findings demonstrate that movement areas of the brain continue to work years after the onset of paralysis. Although many technological hurdles remain, this research is leading to:
  • New methods of restoring movement to people who are physically immobile due to injury or disease.
  • Greater insight into how the brain organizes motor and other tasks.
As we maneuver through our daily environments, our brains are constantly taking what we see, hear, smell, taste, or touch and turning this information into split-second instructions that travel down our spinal cord and out to the muscles of our arms and legs, telling them how and when to move. We see a five-dollar bill on the ground? We stoop down and pick it up. We hear someone shouting, “Watch out!”? We quickly leap out of the way.
Such movements are not possible for the 250,000 Americans with spinal cord injuries, the 1.7 million Americans with limb loss, and others with neurological disorders such as brainstem stroke or amyotrophic lateral sclerosis (ALS) that can result in a devastating total-body paralysis known as “locked-in syndrome.” For people with these disabilities, the brain still fires up the neural signals to instruct an arm to pick up a five-dollar bill or a leg to step to the side, but those commands never make it to the appropriate muscles.
The aim of neural prosthetics is to send the brain’s “Get moving!” messages directly to either an artificial limb or to a paralyzed limb in which muscles are still working. To do this, scientists have developed sensors that detect and decode (with the aid of computer-programmed mathematical algorithms) the patterns of brain cell activity behind specific intended movements. Deciphering these neural signals is extraordinarily tricky. Even the simplest movement—say, lifting an arm—involves a host of interrelated intentions (how fast? what direction? what angle?) and thus the firing of millions of neurons.
Two basic types of sensors are used in neural prosthetics. One records the activity of many brain cells together, either through the scalp (a technology called electroencephalography, or EEG) or just under the scalp (electrocorticography, or ECOG). The other does the same with dozens or more hair-thin microelectrodes in an array about the size of an aspirin implanted directly into the brain’s motor cortex, the area associated with movement. Each microelectrode in the array detects the electrical impulses, called spikes, of single neurons as well as the more diffuse signals seen in the EEG or ECOG.
Both methods have their advantages and disadvantages. Because they take signals from a large area of the brain, the non-invasive EEG and the ECOG methods produce a less precise measurement of movement signals. The microelectrode array provides direct access to the signals related to movement, but must be inserted into brain tissue. Both types of sensors require daily recalibration, and their supporting equipment is bulky and non-portable. Attempts to build automated and portable wireless versions are now underway.
Scientists are also working hard to introduce sensory feedback into BCI technology. The goal: interactive devices—ones that not only send information from the brain to a robotic arm, but also from the arm to the brain. The user would then be able to know the mechanical limb’s location in space and time (an essential sensory feedback known as proprioception) as well as feel the sensation of touch—and, as a result, interact with his or her surroundings with the dexterity of an able-bodied person.
Scientists have already begun to record brain activity in the part of the cortex that processes proprioception, with the aim of creating computer algorithms that could be used to simulate the sensation in an artificial limb. And studies involving monkeys have been able to recreate touch. Although many challenges remain and advances will be incremental, researchers are optimistic that one day the integration of technology that enables communication between the brain and an external device will become a reality.

Stresses prevention through diet, exercise, weight control

Experts Issue New Heart Disease Guidelines for Women

American Heart Association advisory stresses prevention through diet, exercise, weight control


HealthDay news image

(Healthline News) -- Preventing heart attacks and strokes is very similar in women and men, with a few small but important differences, according to new guidelines from the American Heart Association.
Each year, 55,000 more U.S. women than men suffer a stroke, while men are more likely to have heart attacks.
One strong risk factor for stroke is atrial fibrillation, an abnormal heart rhythm that boosts women's risk of stroke by fourfold to fivefold. To prevent stroke, women should make sure they have consulted with their doctor and are taking the right medications to control atrial fibrillation, according to the guidelines.
Women also have other unique risk factors that can increase their chances of stroke, including pregnancy, taking birth control pills, and hormone replacement therapy during menopause.
Certain pregnancy complications including preeclampsia (high blood pressure and protein in the urine), preterm birth, having a baby that's small for its gestational age and gestational diabetes are associated with later heart problems -- something women and their doctors often don't know.
"We consider pregnancy like a physical and metabolic stress test, and complications are like failing the stress test," said Dr. Lori Mosca, chair of the guidelines writing committee and director of preventive cardiology at New York-Presbyterian Hospital. "It's an early indicator of a problem, and there is a common mechanism between pregnancy complications and cardiovascular disease, which is metabolic and vascular dysfunction."
The new guidelines for preventing heart disease in women are published online and in the March 21 print issue of Circulation.
Heart disease is the No. 1 killer of women, yet only 54 percent of women knew this in 2009, according to background information in the report. Still, awareness is up substantially from 1997, when only 30 percent realized heart disease wasn't primarily a "man's disease," the authors noted.
And rising rates of obesity and diabetes threaten to overwhelm the improvements.
Two in three women over the age of 20 are either overweight or obese, researchers have found. And after falling for four decades, death rates from heart disease appear to be rising among U.S. women aged 35 to 54.
Black women are especially hard hit by hypertension (high blood pressure) and heart disease, while Hispanic women have more than double the rates of diabetes as non-Hispanic white women (12.7 percent compared to 6.5 percent).
To reduce the risk of heart disease, women should keep their total cholesterol level at 200 milligrams per deciliter (mg/dL) or less; blood pressure at 120/80 mm Hg; and have a fasting blood glucose under 100 mg/dL.
Women should maintain a body mass index of less than 25, avoid smoking, cut down on salt, eat plenty of fruits, vegetables and whole grains, and do at least 150 minutes of moderate physical activity a week or 75 minutes of vigorous activity, according to the guidelines.
Studies have shown that only about 4 percent of women aged 50 to 79 do all of these things and are considered at the lowest risk for heart disease; 72 percent were at "some risk" of heart disease, while 11 percent were at high risk, defined as a 20 percent or greater chance of having a heart attack or stroke in the next 10 years.
Other updates in the 2011 guidelines include:
  • A recognition that diseases such as lupus and rheumatoid arthritis increase heart disease risk in women.
  • There is little evidence for the use of hormone replacement therapy, antioxidants and folic acid to prevent heart disease in women, and some evidence of potential harm. Nor is there good evidence that the routine use of low-dose aspirin to prevent heart attacks is effective in women.
Scientific evidence regarding women and heart disease is still limited. "The women we see are often sicker, older and have many more co-morbidities than women who participate in clinical trials," Mosca said. For example, women tend to have more side-effects from statins. "The evidence isn't all that strong for statin use as a primary prevention in women," she said. "We want future trials to publish data by gender not just for the benefits but also for the side effects."
Dr. Annabelle Volgman, medical director of the Rush Heart Center for Women in Chicago, said there's still a long way to go in making sure women understand their heart disease risk.
"Fifty-four percent of women know about the risk, but that means 46 percent of women still don't know it's the No. 1 killer," Volgman said. "And although there's been a decline in death rates from heart disease in women, we are seeing more young women 35 to 54 years old having strokes."
A newly approved drug, Pradaxa (dabigatran) is a good alternative to Coumadin (warfarin) for treating atrial fibrillation.
"I find women are more reluctant than men to take drugs. So I always say, "It's Prada with a 'xa,'" Volgman said.
SOURCES: Lori Mosca, M.D., M.P.H., Ph.D., chair, guidelines writing committee, and director, preventive cardiology, New York-Presbyterian Hospital, New York City; Annabelle Volgman, M.D., medical director, Rush Heart Center for Women, Chicago; Feb. 15, 2011, Circulation, online

Premixed Insulin for Type 2 Diabetes: A Guide for Adults


   
You may also view the webinar associated with this topic, "Comparative Effectiveness, Safety, and Indications of Insulin Analogues in Premixed Formulations for Adults With Type 2 Diabetes."
Table of Contents

    * Introduction
    * Fast Facts
    * Type 2 Diabetes and Insulin
    * Learning About Blood Sugar
    * Learning About Insulin
    * Comparing Medicines
    * Questions To Ask Your Doctor
    * Price of Insulin
    * Source
    * For More Information

Introduction
What does this guide cover? 

The information in this guide comes from a government-funded review of research about premixed insulin. This guide compares the benefits, side effects, and costs of a newer type of premixed insulin with other kinds of insulin and pills for diabetes.

Has your doctor or nurse has told you that you need insulin for your type 2 diabetes? There are many kinds of insulin and many different ways to take insulin. This guide can help you learn about them. It can help you talk with your doctor or nurse about whether premixed insulin may be a good choice.
What is not covered in this guide? 

This guide does not cover all the possible ways to treat type 2 diabetes. It does not include information on diet and exercise. It does not cover using insulin in pumps or non-insulin shots like exenatide (Byetta®) or pramlintide (Symlin®). It does not cover the use of insulin by children, pregnant women, or people with type 1 diabetes. 

If your doctor has recommended pills for your type 2 diabetes, the Agency for Healthcare Research and Quality (AHRQ) has published another guide that will be useful for you. That guide is called Pills for Type 2 Diabetes: A Guide for Adults and is available at the Web site: www.effectivehealthcare.ahrq.gov
Fast Facts
Fast facts on premixed insulin

    * When people have type 2 diabetes, their body either does not make enough insulin or does not use insulin as well as it should. Many people with type 2 diabetes need to take insulin shots.
    * Premixed insulin combines two kinds of insulin. The first kind helps the body control blood sugar (blood glucose) all through the day. The second kind helps the body control blood sugar at meal times.
    * There are different types of premixed insulin.
    * The different types of premixed insulin work equally well to lower your A1c. The A1c is a blood test that shows your average blood sugar over the past 2 to 3 months.
    * The chance of your blood sugar dropping too low is the same with the different types of premixed insulin.

Type 2 Diabetes and Insulin

Insulin is a hormone. It is made by an organ near the stomach called the pancreas (PAN-kree-us). Insulin helps the body use sugar from the blood for energy.

With type 2 diabetes, either the pancreas does not make enough insulin or the body does not use insulin as well as it should. Sugar builds up in the blood because the body cannot use it without the help of insulin. This causes blood sugar to stay high. Type 2 diabetes often runs in families.
Why treat diabetes?

If blood sugar stays high for a long time, people may have a higher chance of heart attacks, strokes, and amputations. They may also have a higher chance of blindness, nerve damage, and kidney damage. Keeping your blood sugar at a good level may lower your chance of these problems.
How is type 2 diabetes treated?

The first step in controlling your blood sugar is to eat a balanced diet and be more active. Even small changes can make a big difference. Most people with type 2 diabetes also use pills to help control their blood sugar. 

Over time, many people need insulin to treat their diabetes. About 3 out of every 10 people with type 2 diabetes take insulin.
Learning About Blood Sugar
How is blood sugar tested?

There are two common tests for blood sugar. They can help you and your doctor check how well your blood sugar is under control.
Finger stick

One test is a finger (or forearm) stick that you can do at home. This test is done one or more times a day. You can do it first thing in the morning before you eat (fasting) or at other times of the day, like after a meal. This test tells what your blood sugar level is at that moment in time. The fasting target is usually 80 to 120. After a meal, the target is usually less than 180.
Blood test

The other test is a blood test called A1c (AY-one-see). This test is done at your doctor’s office or a lab a few times a year. The A1c shows the average blood sugar level over the past 2 to 3 months. Usually the goal is for your A1c to be below 7.
Watch for blood sugar that drops too low

All diabetes medicines can cause blood sugar to drop too low. When blood sugar is too low, it’s called hypoglycemia (high-po-gly-SEE-mee-ah).  It can cause you to feel dizzy, sweaty, confused, shaky, hungry, and weak.  

Warning: If you think you may have low blood sugar, eat or drink something with sugar in it right away. Your doctor or nurse may suggest something like hard candy, juice, or glucose tablets.
Learning About Insulin

Insulin helps the body use sugar from the blood for energy. There is always some sugar in the blood. This means the pancreas needs to make small amounts of insulin all through the day. When you eat, your blood sugar goes up. This means the pancreas needs to make extra insulin during meals. When you are more active, your body uses more sugar and needs less insulin.

When you have diabetes, blood sugar stays high. Taking insulin shots is one way to treat diabetes. All insulin used to treat diabetes is made in a lab. 

There are many different kinds of insulin. The kind you may need depends on your activity, eating habits, and how your body responds to insulin. Your doctor or nurse will work with you to match your needs with the kind of insulin that might work well for you.
Insulin that lasts all through the day

There are two kinds of insulin that can control blood sugar all through the day. They are intermediate-acting and long-acting insulin. Both kinds give a constant, low level of insulin all through the day. Usually this means one or two shots a day.  

Insulin that lasts all through the day:
lasts all day
    Generic Name     Brand Name
Intermediate-acting insulin
NPH     Humulin® N

Novolin® N
Long-acting insulin
Insulin detemir     Levemir®
Insulin glargine     Lantus®

Insulin for meal times

After time, one kind of insulin may not be enough to control blood sugar. Your doctor or nurse may add insulin that is used at meal times. There are two kinds of insulin that control blood sugar at meal times. They are fast-acting and short-acting insulin. These kinds of insulin work quickly and last for a short period of time. They cover the high blood sugar from eating a meal. This can mean taking two or more shots a day.

Insulin for Meal Times:
for meal times     Generic Name     Brand Name
Short-acting insulin
Regular     Humulin® R

Novolin® R
Fast-acting insulin
Insulin aspart     NovoLog®
Insulin glulisine     Apidra®
Insulin lispro     Humalog®

Premixed insulin for all day and meals

Some people with diabetes need both kinds of insulin. They need insulin that lasts all through the day and insulin for meal times. Premixed insulin combines both kinds of coverage. It gives you quick coverage for a meal plus longer coverage for other times of the day. If you take premixed insulin, you may need fewer shots each day.

There are different types of premixed insulin.

    * Premixed NPH/regular insulin is made by combining NPH and regular insulin.
    * Newer premixed insulin is the other type of premixed insulin. It is made by combining insulin aspart (NovoLog®) or insulin lispro (Humalog®) with a longer lasting insulin made only for the mix.

Insulin that covers both (all through the day and meal times):
for all day and meal times     Generic Name     Brand Name
Premixed NPH/regular insulin    
NPH/regular 70/30     Humulin® 70/30

Novolin ®70/30
NPH/regular 50/50     Humulin® 50/50
Newer premixed insulin    
Insulin aspart 70/30     NovoLog® Mix 70/30
Insulin lispro 75/25     Humalog® Mix75/25
Insulin lispro 50/50     Humalog® Mix50/50


The numbers used to name the premixed insulin tell you the percent of each kind of insulin in the mixture. The amount of longer lasting insulin is written first. For example, a 70/30 mix means 70 percent of the mix is a longer lasting insulin and 30 percent is quick coverage for a meal.
Comparing Medicines

Research studies have compared newer premixed insulin with other diabetes medicines. This research can help you and your doctor decide whether newer premixed insulin might be a good choice for you. In these charts, a checkmark means research shows the medicine works better than the medicine it is compared with.  
Comparing newer premixed insulin and pills for diabetes

Newer premixed insulin can lower blood sugar more than pills for diabetes. Newer premixed insulin is more likely to cause very low blood sugar. It can also cause more weight gain than diabetes pills.
      Pills for diabetes     Newer premixed insulin
Benefits
Better at lowering A1c.
         
checkmark
Better at lowering fasting blood sugar (before eating).
         
checkmark
Better at lowering blood sugar after meals.
         
checkmark
Side Effects
Less hypoglycemia (very low blood sugar).
   
checkmark
   
Less weight gain.
   
checkmark
   

Comparing newer premixed insulin and long-acting insulin

Newer premixed insulin can lower A1c and blood sugar after meals more than long-acting insulin. But long-acting insulin is better at lowering blood sugar before eating. Newer premixed insulin is more likely to cause very low blood sugar. It can also cause more weight gain than long-acting insulin.
      Long-acting insulin     Newer premixed insulin
Benefits
Better at lowering A1c.
   

   
checkmark
Better at lowering fasting blood sugar (before eating).
   
checkmark
   

Better at lowering blood sugar after meals.
   

   
checkmark
Side Effects
Less hypoglycemia (very low blood sugar).
   
checkmark
   

Less weight gain.
   
checkmark
   

Comparing newer premixed insulin and premixed NPH/regular insulin

The different types of premixed insulin work about the same. Newer premixed insulin is better at lowering blood sugar after meals.
       Premixed
NPH/regular insulin     Newer
premixed insulin
Benefits
Better at lowering A1c.
   
Work the same.
Better at lowering fasting blood sugar (before eating).
   
Work the same.
Better at lowering blood sugar after meals.
   

   
checkmark
Side Effects
Less hypoglycemia (very low blood sugar).
   
Work the same.
Less weight gain.
   
Work the same.
Questions To Ask Your Doctor

All kinds of insulin help the body control blood sugar. Talk to your doctor or nurse about which kind of insulin will work best for you. Here are a few things to ask about. 
How often do I need to take insulin? 

Some kinds of insulin are taken only once a day. Others need to be taken more often or with meals. You may need fewer injections if you can use premixed insulin. Ask your doctor or nurse how often you need to take your insulin.

No matter which insulin you use, be sure to follow the directions included with your medicine.
Are some kinds of insulin easier to measure and inject?

Some people take insulin for coverage all through the day and insulin at meals. Premixed insulin combines both kinds in a mix. This mix may make it easier to measure and inject your insulin.  
Can I use a pen?

To use a syringe, you need to draw up insulin into the syringe. To use a pen, you do not need to draw up insulin. You put a needle on the pen, set the dose with a dial, and give the injection. Most kinds of insulin are available in pens. This option can make it easier to measure and inject insulin. This might be helpful if you have trouble using syringes.
What about the cost?

Use the chart on page 12 to compare the prices of different kinds of insulin. If prescriptions are part of your health insurance plan, check with your plan about the cost to you. If you need help paying for insulin, there may be a program for you. The Partnership for Prescription Assistance can tell you about these programs.

Insulin comes in vials and pens. There are more units of insulin in one package of pens than in one vial.
Generic name1     Brand Name     Price2
One Vial
(1,000 units)     Five-Pack Pens
(1,500 units)
Covers all through  the day
Intermediate-Acting Insulin
NPH insulin     Humulin®N

Novolin®N     $45

$45     $135

$135
Long-Acting Insulin Analogues
Insulin detemir     Levemir®     $95     $190
Insulin glargine     Lantus®     $95     $190
Covers meal times
Short-Acting Insulin
Regular insulin     Humulin®R

Novolin®R     $45

$45     NA

$135
Rapid-Acting Insulin Analogues
Insulin aspart     NovoLog®     $105     $200
Insulin glulisine     Apidra®     $95     $180
Insulin lispro     Humalog®     $105     $200
Covers both (all through the day and meal times)
Premixed Human Insulin
70% NPH/30% regular insulin     Humulin® 70/30

Novolin ® 70/30     $45

$45     $135

$135
50% NPH/50% regular insulin     Humulin® 50/50     $45     NA
Newer premixed Insulin
70% insulin aspart protamine suspension/30% insulin aspart     NovoLog® Mix 70/30     $105     $200
75% insulin lispro protamine suspension/25% insulin lispro     Humalog® Mix75/25     $105     $200
50% insulin lispro protamine suspension/50% insulin lispro     Humalog® Mix50/50     $105     $200

1These drugs were included in the research studies.
2Average Wholesale Price from Red Book, 2008. Price does not include the cost of needles or syringes.
NA = not available in pens.